Institute of Gerontology
I am interested in neural mechanisms of cognitive aging. In my research, I use noninvasive imaging techniques such as Magnetic Resonance Imaging (MRI). I examine cross-sectional differences and longitudinal changes in regional brain volumes and relationships between these changes and measures of cognitive performance in healthy adults.
Neuropathology and Behavior
Raz, N., Gunning, F.M., Head, D., Dupuis, J.H., McQuain, J.M., Briggs, S.D., Thornton, A.E., Loken, W.J. & Acker, J.D. (1997). Selective aging of human cerebral cortex observed in vivo: Differential vulnerability of the prefrontal gray matter. Cerebral Cortex, 7, 268-282.
Raz, N. (2000). Aging of the brain and its impact on cognitive performance: Integration of structural and functional findings. In: F.I.M. Craik and T.A. Salthouse (Eds.) Handbook of Aging and Cognition - II. (Pp.1-90). Mahwah, NJ: Erlbaum.
Raz, N., Lindenberger, U., Rodrigue, K.M., Kennedy, K.M., Head, D. Williamson, A., Dahle, C., Gerstorf, D., & Acker, J.D. (2005). Regional brain changes in aging healthy adults: General trends, individual differences, and modifiers. Cerebral Cortex, 15, 1676-1689.
Raz, N. Dahle, C., Rodrigue, K.M., Kennedy, KM, Land, S., & Jacobs, B.S. (2008). Brain-Derived Neurotrophic Factor Val66Met polymorphism, blood glucose, and memory in healthy adults: The synergy of genetic and vascular risks. Frontiers in Human Neuroscience, 2, article 12, 1-6.
Kennedy KM, Erickson KI, Rodrigue KM, Voss MW, Colcombe SJ, Kramer AF, Acker JD, Raz N.(2009). Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry. Neurobiology of Aging, 30, 1657-1676. Epub 2008 Feb 13. doi:10.1016/j.neurobiolaging.2007.12.020.
Raz, N, Rodrigue, K.M., Kennedy, K.M., & Land, S. (2009). Genetic and vascular modifiers of age-sensitive cognitive skills: Effects of COMT, BDNF, ApoE and hypertension. Neuropsychology. 23, 105-116
Raz, N., Yang, Y., Dahle, C.L., Land, S. (2012). Volume of White Matter Hyperintensities in healthy adults: Contribution of age, vascular risk factors, and inflammation-related genetic variants. BBA: Biochimica et Biophyisica Acta, Section: Molecular Basis of Disease., 1822, 361-369, 2011 Aug 25. [Epub ahead of print].
Raz, N., Schmiedek, F., Rodrigue, K.M., Kennedy, K.M, Lindenberger, U., & Lövdén, M. Differential brain shrinkage over six months shows limited association with cognitive practice, Brain and Cognition, in press.
Rodrigue, K.M., Daugherty, A.M., Haacke, E.M., & Raz, N. The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory performance, Cerebral Cortex, May 29. [Epub ahead of print].
National Institute on Aging, grant 2R37AG011230 Neural Correlates and Modifiers of Cognitive Aging. Funding period: 7/1/05-6/30/10, direct costs: $2,090,389, a MERIT award.
1979-1985 Ph.D. Department of Psychology, University of Texas at Austin.
1976-1979 B.A., Hebrew University, Jerusalem, Israel.